Background: Tissue fibrosis is an integral component of chronic
inflammatory (liver and pancreas) diseases and pancreatic cancer. Activated
pancreatic- (PSC) and hepatic- (HSC) stellate cells play a key role in fibrogenesis.
To identify organ- and disease-specific stellate cell transcriptional fingerprints,
we employed genome-wide transcr... read moreiptional analysis of primary human PSC and HSC
isolated from patients with chronic inflammation or cancer.
Erkan, Mert, Nadine Weis, Zheng Pan, Christian Schwager, Tamar
Samkharadze, Xiaohua Jiang, Ute Wirkner, Nathalia A. Giese, Wilhelm Ansorge, Jürgen
Debus, Peter E. Huber, Helmut Friess, Amir Abdollahi, and Jörg Kleeff. "Organ-,
inflammation- and cancer specific transcriptional fingerprints of pancreatic and
hepatic stellate cells." Molecular Cancer 9, no. 1 (12, 2010):