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Background: Non-healing wounds are a major global health concern and
account for the majority of non-traumatic limb amputations worldwide. However,
compared to standard care practices, few advanced therapeutics effectively resolve
these injuries stemming from cardiovascular disease, aging, and diabetes-related
vasculopathies. While matrix ... read moreturnover is disrupted in these injuries, debriding
enzymes may promote healing by releasing matrix fragments that induce cell migration,
proliferation, and morphogenesis, and plasma products may also stimulate these
processes. Thus, we created matrix- and plasma-derived peptides, Comb1 and UN3, which
induce cellular injury responses in vitro, and accelerate healing in rodent models of
non-healing wounds. However, the effects of these peptides in non-healing wounds in
diabetes are not known. Here, we interrogated whether these peptides stimulate
healing in a diabetic porcine model highly reminiscent of human healing impairments
in type 1 and type 2-diabetes.
Keywords: Diabetic foot ulcer, Angiogenesis, Re-epithelialization,
Molecular medicine, Chronic wound care.
Springer Open.read less
- Sheets, Anthony, Conner J. Massey, Stephen M. Cronk, Mark D.
Iafrati, and Ira M. Herman. "Matrix- and plasma-derived peptides promote
tissue-specific injury responses and wound healing in diabetic swine." Journal of
Translational Medicine 14, no. 2 (12, 2016): 1-13.