The Regulation and Function of CDK5 in Cellular Senescence and Tumorigenesis.

Mao, Daqin.

2011

Description
  • Abstract: The cellular senescence program evolved as a response to diverse forms of damage and stress. Importantly, although senescence was considered a tissue culture phenomenon for many years, recent in vivo studies demonstrated that cellular senescence represents a potent failsafe mechanism against tumorigenesis, by halting aberrant proliferation of cells harboring cancer-promoting mutations in... read more
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