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Craniofacial deformities are common developmental defects in humans, and
these birth defects cannot be treated, or the only form of treatment is an expensive and
invasive surgery. Thus, there is a critical need to study not just the causes of
craniofacial defects in vertebrate model systems, but also potential resolutions and
treatments for these craniofacial defects. Previous work by the ... read moreMcLaughlin lab
determined that Xenopus laevis tadpoles with craniofacial deformities improve their
overall morphology prior to metamorphosis by remodeling malformed craniofacial tissues,
such as cartilage and eye tissue. In these works, we show that this self-correction
process also includes the remodeling and repair of brain tissue. To elucidate the
mechanism by which this self-correction process occurs, brain tissue differentiation and
cerebrospinal fluid flow were examined in control and malformed brains. In addition, the
genetic factors involved in the self-correction of abnormal brain tissue were studied
through RNA-seq and RT-qPCR procedures.read less
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