Genetic & Genomic Analysis of the mRNA 3' End Processing Subunit Pcf11 Suggests an Expanded Role in Gene Expression.

Hoskinson, Derick.


  • Abstract: Production of mature mRNA is a multistep process requiring many proteins that is essential for proper cellular function. Defects in mRNA maturation lead to radical changes in development, growth and viability of the cell. The essential mRNA 3' end processing subunit, Pcf11, is required for the cleavage and polyadenylation of nascent mRNAs and for proper termination of RNA polymerase II t... read more
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