| Description |
-
Trinucleotide repeats are repetitive sequences in the genome prone to both fragility and instability. The Saccharomyces cerevisiae gene TRF4 may function in DNA repair or cohesion mechanisms, in addition to an RNA-level role leading to the degradation of aberrant RNAs. This study shows that Δtrf4 displays increased fragility and instability in CAG repeat tracts over wild-type yeast, suggesting a ... read morerole for TRF4 in the maintenance of CAG repeats in the genome. In contrast, the mutant for TRF4's homologue TRF5 displays no increased repeat fragility or instability over the wild-type. In order to further understand TRF4's potential role in maintenance of CAG repeats, genetic experiments were performed to determine whether this phenotype can be attributed to a role of TRF4 in double-stranded break repair, the potential fork stabilization pathway of the Ctf18 replication factor C-like complex, or post-replication repair.read less
|
|---|
This object is in collection
