Synthesis of Zwitterionic Lipidoids and its Biomedical Applications
Developing drug delivery systems that can efficiently and effectively release
therapeutic payload without inducing side effects has proved to be a difficult task.
This is why it is becoming increasingly important to be able to synthesize tunable drug
carriers where their physical and chemical properties can be specific to the targeted
application. Zwitterionic lipidoids are an emerg... read moreing new class of lipid-like material
that have neutral charge. Many studies have cited zwitterionic lipidoids to exhibit
excellent stability and low cytotoxicity due to their unique structures. As result, they
play a key role in advancing drug nanotechnology. Thus, it is critical to expand the
combinatorial library of synthesized zwitterionic lipidoids. By conjugating different
polar heads groups with hexadecyl acrylate, new zwitterionic lipidoids were developed.
Although amino acid based zwitterionic lipidoids have been studied in literature, the
particular use of β-alanine as a head group has not been done. Its resulting
zwitterionic lipidoid produced significantly lower cytotoxicity in comparison to current
literature and makes this a novel approach to drug delivery. Their properties were then
evaluated and their biomedical applications
Thesis (M.S.)--Tufts University, 2017.
Submitted to the Dept. of Biomedical Engineering.
Advisor: Qiaobing Xu.
Committee: Xiaocheng Jiang, and Samuel Thomas.
Keyword: Biomedical engineering.read less