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Background: Bioelectric gradients among all cells, not just within
excitable nerve and muscle, play instructive roles in developmental and regenerative
pattern formation. Plasma membrane resting potential gradients regulate cell
behaviors by regulating downstream transcriptional and epigenetic events. Unlike
neurons, which fire rapidly ... read moreand typically return to the same polarized state,
developmental bioelectric signaling involves many cell types stably maintaining
various levels of resting potential during morphogenetic events. It is important to
begin to quantitatively model the stability of bioelectric states in cells, to
understand computation and pattern maintenance during regeneration and
remodeling.
Keywords: Computational, Bistability, Bioelectric, Ion channels, Resting
potential, Memory, Ion flux, Modeling, Xenopus.
Springer Open.read less
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