Kinase Activities of RIPK1 and RIPK3 Direct Host Immune Cytokine Production that Manifests Independent of Cell Death

Saleh, Danish.


  • Abstract: Macrophages function as a crucial component of the innate immune system in sensing bacterial pathogens and promoting local and systemic inflammation. RIPK1 and RIPK3 are serine/threonine kinases that have been well-characterized as key regulators of programmed necrotic cell death or necroptosis that is dependent on downstream pseudokinase MLKL. The work presented in the ensuing ... read more
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