A robust Pax7EGFP mouse that enables the visualization of dynamic behaviors of muscle stem cells.

Tichy, Elisia D.

Sidibe, David K.

Greer, Christopher D.

Oyster, Nicholas M.

Rompolas, Panteleimon.

Rosenthal, Nadia A.

Blau, Helen M.

Mourkioti, Foteini.

2018

Description
  • Background: Pax7 is a transcription factor involved in the specification and maintenance of muscle stem cells (MuSCs). Upon injury, MuSCs leave their quiescent state, downregulate Pax7 and differentiate, contributing to skeletal muscle regeneration. In the majority of regeneration studies, MuSCs are isolated by fluorescence-activated sorting (FACS), based on cell surface markers. It is known that ... read more
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