Background: The increasing problem of infections due to
multidrug-resistant Gram-negative bacteria has led to re-use of polymyxins in several
countries. However, there are already clinical isolates of Gram-negative bacteria
that are resistant to all available antibiotics, including
Falagas, Matthew, Ioannis A. Bliziotis, Sofia K. Kasiakou,
George Samonis, Panayiota Athanassopoulou, and Argyris Michalopoulos. "Outcome of
infections due to pandrug-resistant (PDR) Gram-negative bacteria." BMC Infectious
Diseases 5, no. 1 (12, 2005): 1-7.