Genetic control of DNA repeat expansions and mutagenesis.

Shah, Kartik.

2017-04-24T15:11:27.728Z

Description
  • Abstract: Expansions of simple DNA repeats are known to cause several devastating neurodegenerative diseases in humans. Experimental systems mimicking large-scale human expansions have (1) proven difficult to develop and (2) been only moderately successful. Different cellular processes - replication, repair, homologous recombination and transcription, have been implicated in repeat instability in ... read more
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tufts:22007
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