A Phenotypic Screen Identifies Cyclic Peptide Compounds that Induce Repeat Expansion in Yeast.

Economos, Nicholas G.

2013

Description
  • Expansion of repeat sequences in the eukaryotic genome can result in dangerous consequences often implicated in the pathology of severe human diseases. Out-of-context telomeric extension in immortalized cancer cell lines and expanded GAA repeat tracts in sufferers of the disease Friedreich's ataxia are two such examples. The mechanisms related to repeat expansion have been widely investigated, but... read more
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