Vav2 Inhibits T Cell Calcium Signaling by Activating Cdc42.

Fray, Michael A.


  • Abstract: Vav proteins are tyrosine kinase-dependent guanine nucleotide exchange factors (GEFs) essential for a functional immune system. This family of proteins consists of three mammalian isoforms, Vav1, Vav2, and Vav3. Studies in mice have shown that knocking out all three of these isoforms leads to an almost complete loss in the number and function of T and B cells (Fujikawa et al., 2003), ser... read more
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