Plausibility of stromal initiation of epithelial cancers without a mutation in the epithelium: a computer simulation of morphostats.

Baker, Stuart G.

Soto, Ana M.

Sonnenschein, Carlos.

Cappuccio, Antonio.

Potter, John D.

Kramer, Barnett S.

2009

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  • Background: There is experimental evidence from animal models favoring the notion that the disruption of interactions between stroma and epithelium plays an important role in the initiation of carcinogenesis. These disrupted interactions are hypothesized to be mediated by molecules, termed morphostats, which diffuse through the tissue to ... read more
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  • Baker, Stuart, Ana M. Soto, Carlos Sonnenschein, Antonio Cappuccio, John D. Potter, and Barnett S. Kramer. "Plausibility of stromal initiation of epithelial cancers without a mutation in the epithelium: a computer simulation of morphostats." BMC Cancer 9, no. 1 (12, 2009): 1-11.
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