| Description |
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Background: Inflammation is a major cause of cartilage destruction and leads to the imbalance of metabolic activities in the arthritic joint. Pigment epithelium-derived factor (PEDF) has been reported to have both pro- and anti-inflammatory activities in various cell types and to be upregulated in the arthritic joint, but its role in joint destruction is unclear. Our aim was to investigate the role ... read moreof PEDF in cartilage degeneration under inflammatory conditions.
Keywords: Pigment epithelium-derived factor, Matrix, cartilage, IL-1β, MMPs, Arthritis, Inflammation, SERPINF1, Age-related.
Springer Open.read less
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| Citation |
- Nakamura, Daisy, Judith M. Hollander, Tomoya Uchimura, Heber C. Nielsen, and Li Zeng. "Pigment Epithelium-Derived Factor (PEDF) mediates cartilage matrix loss in an age-dependent manner under inflammatory conditions." BMC Musculoskeletal Disorders 18, no. 1 (12, 2017): 1-12.
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