Integrating protein engineering and bioorthogonal click conjugation for extracellular vesicle modulation and intracellular delivery.

Wang, Ming.

Altinoglu, Sarah.

Takeda, Yuji S.

Xu, Qiaobing.


  • Exosomes are small, cell-secreted vesicles that transfer proteins and genetic information between cells. This intercellular transmission regulates many physiological and pathological processes. Therefore, exosomes have emerged as novel biomarkers for disease diagnosis and as nanocarriers for drug delivery. Here, we report an easy-to-adapt and highly versatile methodology to modulate exosome ... read more
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  • Wang M, Altinoglu S, Takeda YS, Xu Q (2015) Integrating Protein Engineering and Bioorthogonal Click Conjugation for Extracellular Vesicle Modulation and Intracellular Delivery. PLoS ONE 10(11): e0141860. doi:10.1371/journal.pone.0141860.
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