Discovery and characterization of HERV-K (HML-2) integrations in humans and gorillas

Williams, Zachary.

2017

Description
  • Abstract: The HERV-K (HML-2) endogenous retrovirus (ERV) clade is the most recently active ERV group in humans, and the only group with human-specific integrations, some of which are insertionally polymorphic. A subset of HML-2 proviruses has some or all ORFs intact, with detectable signals of purifying selection, and expression of these proviruses has been associated with cancer and other di... read more
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