Regulation of V-ATPase Activity and its Role in Breast Cancer Metastasis

McGuire, Christina.


  • The vacuolar H+ ATPase (V-ATPase) is an ATP driven proton pump made up of fourteen different subunits that are arranged into two domains, the peripheral V1 domain and the integral V0 domain. Present in both intracellular membranes and at the plasma membrane of specialized cell types, V-ATPase activity is required for numerous basic cellular processes. Dysregulation of V-ATPase activity has ... read more
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