Mouse tail regeneration with Biodome.
- Every organism in nature regenerates to certain extent, yet the process of regeneration is still not fully understood. While prosthetics are able to provide a limited solution for limb amputations, they are not able to fully restore the lost function and structure of the original limb. Regeneration requires complex orchestration of cell migration, proliferation, and outgrowth, controlled by the ... read morebioelectrical and biochemical pathways. The Biodome project aims to induce regenerative pathways in an amputated murine specie tail by altering membrane potential and providing external electrical stimulations. Biodome is an apparatus designed to deliver chemical solutions, while enabling electrical stimulations. By altering the bioelectrical signals at the wound, the Biodome project was able to produce preliminary regenerative responses by preventing formation of stratum corneum and promoting bone remodeling.read less
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