A reductionist approach: Defining the scope of selective glycation, a native non-enzymatic posttranslational modification

Fraser, Sasha.

2018

Description
  • Abstract: In the present work, a one-bead-one-compound (oboc) arginine-containing peptide library was interrogated to address the unmet need to unravel the microenvironment effect of reactive arginine sites towards MG, the most potent and prevalent glycating agent in vivo. We implemented three distinct colorimetric detection schemes to screen the i-2, i-1, i+2 and i+1 positions flanking arginine i... read more
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02871743b
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