Developing peptide inhibitors of Shp2 through a one-bead-one-compound approach

Tomlinson, Kira Leigh

Shp2 is a protein tyrosine phosphatase that is mutated in Noonan syndrome and myeloid neoplasms, and aberrantly activated in HER-positive breast cancers and H. pylori-induced gastric cancer. Shp2 has been found to act upstream of a variety of growth factor and cytokine signaling pathways, but its role within the cell has not been fully elucidated. Potent and specific inhibitors of Shp2 are needed ... read more

This object is in collection:
Undergraduate honors theses
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Tufts University. Department of Chemistry.
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http://hdl.handle.net/10427/013445
ID: tufts:sd.0000647
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