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This is an
undergraduate thesis written in for the Tufts Chemistry Department. All research was
conducted at the Amy Yee Lab at the Tufts University Sackler School of Biomedical
Sciences. This thesis examines the molecular effects of treating triple negative breast
cancer with epigallocatechin 3-gallate (EGCG), a compound isolated from green tea, and
decitabine (DAC), a chemotherapeutic DNA ... read moredemethylating agent. Using RNA sequencing, a
transcriptomic bioinformatic analysis was employed to examine other pathways impacted by
EGCG/DAC
treatment.read less
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