Rational Design of Inhibitors of Protein-Protein Interactions Based on Computational Grafting of Hot Loops on to Stable Scaffolds

Bird, Michael J.
2016

Peptides and small, well-folded proteins are important and useful classes of molecules for drug development. Structured peptides and small protein scaffolds can be used to recapitulate natural 3D binding epitopes in a number of ways, including the application of covalent “staples” and by grafting epitopes onto a suitable scaffold protein. These methods, among others, require a known 3D binding epi... read more

This object is in collection:
Undergraduate honors theses
Subjects
Protein-protein interactions.
Proteins--Inhibitors.
Protein binding.
Antigenic determinants.
Tufts University. Department of Chemistry.
Permanent URL
http://hdl.handle.net/10427/009564
ID: tufts:sd.0000388
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Usage: Detailed Rights