Rational Design of Inhibitors of Protein-Protein Interactions Based on Computational Grafting of Hot Loops on to Stable Scaffolds.

Bird, Michael J.

Peptides and small, well-folded proteins are important and useful classes of molecules for drug development. Structured peptides and small protein scaffolds can be used to recapitulate natural 3D binding epitopes in a number of ways, including the application of covalent “staples” and by grafting epitopes onto a suitable scaffold protein. These methods, among others, require a known 3D binding epi... read more

This object is in collection:
Undergraduate Honors Theses
Protein-protein interactions.
Protein binding.
Antigenic determinants.
Tufts University. Department of Chemistry.
Permanent URL
ID: tufts:sd.0000388
To Cite: DCA Citation Guide
Usage: Detailed Rights