The effect of overexpressed GGA3 on BACE1 in mouse - in vivo model for Alzheimer’s Disease.

Ma, Martin.

β-site Amyloid Precursor Protein-cleaving enzyme-1 (BACE1) is the key protein that facilitates the production of amyloid-β protein (Aβ), which is the major cause of the symptoms of Alzheimer’s Disease. It has been shown that Golgi-localized γ-ear-containing ADP-ribosylation factor binding protein 3 (GGA3) inversely regulates the level of BACE1 in in vitro model. In this experiment, 3 different tra... read more

Amyloid beta-protein.
Alzheimer's disease--Molecular aspects.
Transgenic mice.
Tufts University. Department of Neuroscience.
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ID: tufts:sd.0000360
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