Targeting a "hot loop" in the oncogenic Skp2-Cks1 protein-protein interaction with cyclic peptide inhibitors

Keenan, Caitlin M.
2015

This project involves the development of conformationally constrained mimetic peptides, informed by the Loop Finder program developed by the Kritzer Lab, to block the interaction between two subunits of a ubiquitin ligase. This protein-protein interaction is involved in regulating progression from G1 to S phase of the cell cycle and is associated with many types of cancer. Submitted in partial fu... read more

Subjects
Summer Scholars Program.
Tufts University. Department of Chemistry.
Peptides.
Kritzer Laboratory (Tufts University)
Permanent URL
http://hdl.handle.net/10427/008313
ID: tufts:sd.0000357
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