Optimization of a bacterial expression system for the purification and activity analysis of a Caenorhabditis elegans chitin deacetylase.Chirunomula, Molly M.
Parasitic nematodes cause severely debilitating diseases such as lymphatic filariasis and onchocerciasis. One potential therapeutic target for the treatment or prevention of nematode infections is chitin deacetylase (CDA). CDA converts the biologically important carbohydrate polymer of chitin (beta-1,4-linked N-acetylglucosamine) to chitosan. The effectiveness of this process has been correlated t... read more