Assessing the Effects of Cis and Trans Factors on Fragility at the Common Fragile Site FRA16D.Haouzi, Alice Alexandra.
Common Fragile Sites (CFSs) are regions within chromosomes prone to breakage and characterized by late replication. FRA16D, located within the tumor suppressor gene WWOX, is the second most highly expressed CFS in humans and has been associated with a variety of cancer cell lines. It is our hypothesis that multiple sequences within FRA16D work in a concerted effort to cause expression of the CFS. ... read more