Glutamate hyperexcitability and aggression during withdrawal from escalated ethanol consumption in outbred male mice.Nathanson, Anna J.
Ethanol withdrawal syndrome, characterized by glutamatergic hyperexcitability in the brain, is a defining characteristic of alcohol dependence. Glutamate hyperexcitability and an upregulation of NMDA receptors have been observed in the brains of mice in withdrawal from ethanol consumption. The present study examined the effects of the uncompetitive NMDA receptor antagonist memantine o... read more
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