A White-Box Approach to Function-Parameter Co-Estimation for Kinetic Models of Biochemical Networks

Hopkins, Calvin Michael

Kinetic modeling attempts to describe the time-dependent behavior of every enzyme-catalyzed reaction in the network. Systems of ordinary differential equations express each reaction rate as a function of metabolite concentrations and rate constant parameters. The mechanistic knowledge of enzyme kinetics however is not always available. Furthermore, estimating a consistent set of rate... read more

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