Synthesis of a Ganglioside GM1 Anchor for Membrane Tethered Ligands of G-Protein Coupled Receptors.Sidhom, Eriene-Heidi.
G-protein coupled receptors, as a class of proteins, are most important therapeutically. It is estimated that over 50% of prescription drugs target these receptors.1 At nearly 1000 proteins, this family is divided into 5 classes, or families. The largest of these is Class A, the Rhodopsin family. This class is identifiable by conserved sequences which are critical for membrane activati... read more