An investigation into biological and biochemical functions of SIRT5 in regulation of lipid metabolism

Lee, Jaewon

In lower organisms such as yeast, silent information regulator 2 (Sir2), a NAD-dependent deacetylase, links the metabolic activity of yeast to its aging phenotype. Mammals have seven Sir2 homologs, SIRT1-7, which have conserved NAD-dependent deacetylase and/or ADP-ribosyltransferase activities. Although mammalian sirtuins have not been shown to regulate life span, they affect various cellular proc... read more

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