Determining the Signal Transduction Pathway Utilized in the Production of TNF- in Neurotensin-treated HMC-1 Human Mast Cells.

Saurman, Virginia E.

The purpose of this experiment was to determine the signal transduction pathway(s) that are activated to produce tumor necrosis factor alpha (TNF-) in HMC-1 human mast cells upon stimulation with neurotensin (NT). Phorbol 12-myristate 13-acetate (PMA) and the calcium ionophore A23187 were used as positive controls to elicit TNF- production in HMC-1, as these had been previously confirm... read more

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Undergraduate Honors Theses
Tufts University. Department of Biology.
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