Constructing a model to test the effects of transcription on CAG repeat instability in yeast

Jong, Robyn M.

Trinucleotide repeats have been associated with numerous hereditary neurological disorders in humans. The inheritance of these diseases correlates with the tendency of tandem trinucleotide repeats to expand and contract in length, a phenomenon called instability. In recent years, transcription through repeat tracts has been shown to destabilize CAG repeat lengths in human cells, mice, ... read more

This object is in collection:
Undergraduate Honors Theses
Trinucleotide repeats.
Genetic disorders.
Yeast fungi--Genetics.
Tufts University. Department of Biology.
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ID: tufts:UA005.010.074.00001
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