The Effect of the Polymorphic (AT)n Dinucleotide Repeat Length on the Fragility of the Flex1 Region within the Human Common Fragile Site FRA16DLee, Soo Mi Alison.
Common fragile sites are chromosomal regions that are susceptible to breakage. The second most highly expressed common fragile site, FRA16D, is located within the WWOX tumor suppressor gene and has been associated with chromosomal instability in various cancers. Flex1 is a ~500 bp AT-rich region located within FRA16D and contains a polymorphic (AT)n dinucleotide repeat. The Flex1 region has been s... read more