Characterization of the role of Drosophila melanogaster Pol32 in Homologous Recombination and DNA Repair.Shusterman, Michael.
Double strand breaks (DSBs) in DNA represent one of the most toxic and dangerous classes of DNA lesions. DSB repair (DSBR) occurs through two canonical pathways, homologous recombination (HR) or nonhomologous end joining (NHEJ). In Drosophila melanogaster, DSBR of P-element induced breaks is believed to occur through the HR pathway known as synthesis dependent strand annealing (SDSA). A variety of... read more