Mechanisms of expansions of a pentanucleotide repeat responsible for spinocerebellar ataxia 10.

Cherng, Nicole Binanne.
2010

Spinocerebellar ataxia type 10 (SCA10) is an autosomal dominant disease characterized by ataxia and, in some cases, epilepsy, which is caused by expansions of the (ATTCT)n repeat within an intron of the ATXN10 gene. The repeat can expand from 10-22 copies in normal individuals up to 4,500 repeats in SCA10 patients. To understand the mechanisms responsible for (ATTCT)n repeat instability, we set up... read more

This object is in collection:
Undergraduate honors theses
Subjects
Tufts University. Department of Biology.
Permanent URL
http://hdl.handle.net/10427/70310
ID: tufts:UA005.010.047.00001
To Cite: DCA Citation Guide
Usage: Detailed Rights