Cloning and Expression of Neurotrophic Trypanosoma cruzi Ribosomal Proteins

Mugnier, Monica

Trypanosoma cruzi, the infectious agent of Chagas' Disease, has a mimic of nerve growth factor (NGF), known as parasite-derived neurotrophic factor (PDNF). PDNF binds to the NGF receptor TrkA and promotes the survival and differentiation of neuronal cells, as well as entry into the cell by T. cruzi. A screen for T. cruzi proteins that mimic other neurotrophic factors was performed, and a T. cruzi ... read more

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Undergraduate honors theses
Department of Biology
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