Effects of CRF-R1 and Opioid Antagonism on Alcohol Intake in C57BL/6J Mice

Kayyali, Tala M.

Modulation of corticotropin-releasing factor (CRF) neural pathways and the opioid system has been promising for reducing ethanol intake in alcohol-dependent rodents and humans. Specifically, CRF receptor 1 (CRF-R1) antagonism in brain sites such as the dorsal raphé nucleus (DRN) has been suggested to alter output involved in alcohol drinking. Naltrexone, an opioid antagonist, is a drug that is cu... read more

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