Age-Dependent Changes in the Sphingolipid Composition of Mouse CD4+ T Cell Membranes and Immune Synapses Implicate Glucosylceramides in Age- Related T Cell Dysfunction

Molano, Alberto
Huang, Zhaofeng
Marko, Melissa G.
Azzi, Angelo
Wu, Dayong
Bunnell, Stephen C.
Meydani, Simin Nikbin
2012-10

To determine whether changes in sphingolipid composition are associated with age-related immune dysfunction, we analyzed the core sphingolipidome (i.e., all of the metabolites through the first headgroup additions) of young and aged CD4+ T cells. Since sphingolipids influence the biophysical properties of membranes, we evaluated the compositions of immune synapse (IS) and non-IS fract... read more

Subjects
Provost Open Access Fund
Jean Mayer USDA Human Nutrition Research Center on Aging
Sackler Graduate School of Biomedical Sciences. Department of Pathology
Permanent URL
http://hdl.handle.net/10427/77765
Original publication
Molano, Alberto, Zhaofeng Huang, Melissa G. Marko, Angelo Azzi, Dayong Wu, et al. "Age-Dependent Changes in the Sphingolipid Composition of Mouse CD4+ T Cell Membranes and Immune Synapses Implicate Glucosylceramides in Age-Related T Cell Dysfunction." PLoS ONE 7, no. 10 (October 2012).
ID: tufts:PB.002.00016
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