Stapled peptides: How to be quick on the uptake.

Kritzer, Joshua A.
2016.

Stapled helices are promising compounds for inhibiting intracellular protein-protein interactions, but the discovery of peptides with the key property of cellular uptake has taken place largely through trial and error. A new study defines physicochemical parameters for designing hydrocarbon-stapled helices with a greater likelihood of cellular uptake.

Subjects
Machine learning.
Peptides.
Tufts University. Department of Chemistry.
Permanent URL
http://hdl.handle.net/10427/013733
Original publication
Kritzer, J.A. Stapled peptides: How to be quick on the uptake. Nat. Chem. Biol. 2016 12(10), 764-765. doi:10.1038/nchembio.2183.
ID: tufts:23300
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