Comprehensive analysis of loops at protein-protein interfaces for macrocycle design.Kritzer, Joshua A.
Eshelman, Matthew R.
Inhibiting protein-protein interactions (PPIs) with synthetic molecules remains a frontier of chemical biology. Many PPIs have been successfully targeted by mimicking -helices at interfaces, but most PPIs are mediated by non-helical, non-strand peptide loops. We sought to comprehensively identify and analyze these loop-mediated PPIs by writing and implementing LoopFinder, a customizable program t... read more
- Tufts University. Department of Chemistry.
- Permanent URL
- Original publication
- Kritzer, J.A., Gavenonis, J., Sheneman, B., Siegert, T., Eshelman, M.R. Comprehensive analysis of loops at protein-protein interfaces for macrocycle design. Nat. Chem. Biol. 2014 10(9), 716-722. doi:10.1038/nchembio.1580.