Comprehensive analysis of loops at protein-protein interfaces for macrocycle design.

Kritzer, Joshua A.
Gavenonis, Jason.
Sheneman, Bradley.
Siegert, Timothy.
Eshelman, Matthew R.
2014.

Inhibiting protein-protein interactions (PPIs) with synthetic molecules remains a frontier of chemical biology. Many PPIs have been successfully targeted by mimicking -helices at interfaces, but most PPIs are mediated by non-helical, non-strand peptide loops. We sought to comprehensively identify and analyze these loop-mediated PPIs by writing and implementing LoopFinder, a customizable program t... read more

Subjects
Peptides.
Proteins.
Tufts University. Department of Chemistry.
Permanent URL
http://hdl.handle.net/10427/013732
Original publication
Kritzer, J.A., Gavenonis, J., Sheneman, B., Siegert, T., Eshelman, M.R. Comprehensive analysis of loops at protein-protein interfaces for macrocycle design. Nat. Chem. Biol. 2014 10(9), 716-722. doi:10.1038/nchembio.1580.
ID: tufts:23299
To Cite: DCA Citation Guide
Usage: Detailed Rights