Metal-binding and redox properties of substituted linear and cyclic ATCUN motifs.Kritzer, Joshua A.
Neupane, Kosh P.
The amino-terminal copper and nickel binding (ATCUN) motif is a short peptide sequence found in human serum albumin and other proteins. Synthetic ATCUN-metal complexes have been used to oxidatively cleave proteins and DNA, cross-link proteins, and damage cancer cells. The ATCUN motif consists of a tripeptide that coordinates Cu(II) and Ni(II) ions in a square planar geometry, anchored by chelation... read more
- Tufts University. Department of Chemistry.
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- Original publication
- Neupane, K.P., Aldous, A.R., and Kritzer, J.A. Metal-binding and redox properties of substituted linear and cyclic ATCUN motifs. J. Inorg. Biochem. 2014 139, 65-76. https://doi.org/10.1016/j.jinorgbio.2014.06.004.