Chemical biology is now able to discover molecules that manipulate virtually any biological target or process. It remains a grand challenge to leverage these molecules into useful probes that can be used to address unsolved problems in biology.
Kritzer, J.A. Grand Challenge Commentary: Beyond Discovery: Probes That See, Grab and Poke. Nat.Chem. Biol. 2010 6(12), 868-870. doi:10.1038/nchembio.469.
