Potential C-terminal-domain inhibitors of heat shock protein 90 derived from a C-terminal peptide helix.

Kritzer, Joshua A.

Gavenonis, Jason.

Jonas, Nicholas E.

2014.

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  • Hsp90 is a molecular chaperone implicated in many diseases including cancer and neurodegenerative disease. Most inhibitors target the ATPase site in Hsp90's N-terminal domain, with relatively few inhibitors of other domains reported to date. Here, we show that peptides derived from a short helix at the C-terminus of Hsp90 show micromolar activity as Hsp90 inhibitors in vitro. These inhibitors do ... read more
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  • Gavenonis, J.; Jonas, N. E.; Kritzer, J. A. Potential C-Terminal-Domain Inhibitors of Heat Shock Protein 90 Derived from a C-Terminal Peptide Helix. Bioorganic & Medicinal Chemistry 2014, 22 (15), 3989-3993 DOI: 10.1016/j.bmc.2014.06.006.
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