Versatile Substrates and Probes for IgA1 Protease Activity.

Kritzer, Joshua A.
Choudary, Santosh K.
Qiu, Jiazhou.
Plaut, Andrew G.
2013.

Bacterial meningitis is a severe infectious disease with high mortality. Gram-positive and Gram-negative bacteria that cause meningitis secrete immunoglobulin A1 (IgA1) proteases to assist in mucosal colonization, invasion, and immune evasion. IgA1 proteases have unique selectivity, with few reported substrates other than IgA1 from human tissue. Here we describe the design, characterization, and a... read more

Subjects
Meningitis.
Immunoglobulins.
Peptides.
Tufts University. Department of Chemistry.
Permanent URL
http://hdl.handle.net/10427/013723
Original publication
Choudary, S. K., Qiu, J., Plaut, A. G. and Kritzer, J. A. (2013), Versatile Substrates and Probes for IgA1 Protease Activity. ChemBioChem, 14: 2007-2012. doi:10.1002/cbic.201300281
ID: tufts:23290
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