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Abstract: Obesity
promotes the development of a variety of diseases including type 2 diabetes,
cardiovascular disease, fatty liver, and cancer. As obesity is characterized by a
chronic state of low-grade inflammation distinguished by immune cell infiltration into
the adipose tissue, a model demonstrating this inflammatory state is needed to better
understand the disease itself as well as how ... read moreit affects different patients. Utilizing a
3D tissue-engineered in vitro adipose construct integrating a 3D silk fibroin porous
scaffold and the multiple cell types found in adipose tissue, an induced inflammatory
model was created by the addition of THP-1 derived macrophages. The model demonstrated
increased cell proliferation, higher rates of lipolysis, and an upregulation of leptin
production in a patient specific manner. The results demonstrate the successful
development of an inflammatory state and highlight the patient specific response to
inflammatory conditions.
Thesis (M.S.)--Tufts
University, 2017.
Submitted to the Dept. of
Biomedical Engineering.
Advisor: David
Kaplan.
Committee: Lauren Black, and Kyongbum
Lee.
Keyword: Biomedical
engineering.read less
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