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Abstract:
Microneedles (MNs) are a form of transdermal drug delivery capable of delivering an
antigen or vaccine in a painless fashion. Silk is a biodegradable and biocompatible
polymer with good mechanical strength, offering a suitable material for the fabrication
of MNs. The current fabrication of silk MNs is achieved through either clean-room based
lithography or machine shop-based ... read moremicromachining. In the present work, we investigated
an alternative fabrication method that can be performed on the bench-top without the
need for special facilities or equipment. Additionally we investigated drug release from
these silk MNs in vitro, looking at different loadings and coatings of drugs to
characterize release into the skin. In vivo studies investigated the use of silk MNs to
deliver a model antigen, Ovalbumin, to illicit an immune response in
rats.
Thesis (M.S.)--Tufts University,
2013.
Submitted to the Dept. of Biomedical
Engineering.
Advisor: David
Kaplan.
Committee: Qiaobing Xu, and Gary
Leisk.
Keyword: Biomedical
engineering.read less
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