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Abstract: Prototype
medical devices developed to prove laboratory science are manufactured at small
quantities for bench-top testing; however, in order to provide high quality clinical
data for validation, production must be scaled up to make hundreds of devices for
clinical trials. One example of a device undergoing this transition to clinical trials
is a disposable micro-fluidic cartridge ... read moredesigned to study blood clotting at
Massachusetts Institute of Technology's Clinical Research Center. This thesis aims to
down-select from a variety of polymer processing techniques to determine the appropriate
method to create these micro-fluidic cartridges for clinical trials. Additionally, this
thesis develops a modeling technique used to predict the robustness of the selected
manufacturing process. The modeling technique and manufacturing process are then used to
redesign and build cartridge parts for clinical
trials.
Thesis (M.S.)--Tufts University,
2015.
Submitted to the Dept. of Mechanical
Engineering.
Advisors: Kumaran Kolandaivelu, and
Jason Rife.
Committee: Anil
Saigal.
Keywords: Mechanical engineering, Plastics,
and Biomedical engineering.read less
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