Carbohydrates in drug discovery: 1. Methods for solid phase glycoconjugate synthesis. 2. Synthesis and evaluation of carbohydrate toll-like-receptor agonist conjugates for S. pneumoniae vaccines.Nguyen, Son.
Abstract: This dissertation describes two major studies directed toward: 1) Thiophilic promoters for the direct transfer of resin-bound oligosaccharides to complex acceptors in solid-phase organic synthesis, and 2) Studies toward development of well-defined carbohydrate antigen-based S. pneumoniae vaccines. Chapter 1 provides some background in glycoconjugate synthesis and glycorandomization. Chap... read more
- Tufts University. Department of Chemistry.
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