Carbohydrates in drug discovery: 1. Methods for solid phase glycoconjugate synthesis. 2. Synthesis and evaluation of carbohydrate toll-like-receptor agonist conjugates for S. pneumoniae vaccines.

Nguyen, Son.
2017-04-20T13:59:23.822Z

Abstract: This dissertation describes two major studies directed toward: 1) Thiophilic promoters for the direct transfer of resin-bound oligosaccharides to complex acceptors in solid-phase organic synthesis, and 2) Studies toward development of well-defined carbohydrate antigen-based S. pneumoniae vaccines. Chapter 1 provides some background in glycoconjugate synthesis and glycorandomization. Chap... read more

Subjects
Tufts University. Department of Chemistry.
Permanent URL
http://hdl.handle.net/10427/012023
ID: tufts:21498
To Cite: DCA Citation Guide